Possible causes of peeling skin on the soles of the feet include tinea pedis, herpes sweat, drug rash, vitamin deficiency, etc., which can be treated and rooted out with the help of medication and enhanced nutrition. 1. Tinea pedis: a variety of fungal infections of the foot can lead to tinea pedis, which causes the soles of the feet, heels and other parts of the blisters, vesicles, peeling and other symptoms, such patients can be applied locally bifonazole cream and other antifungal ointment to help improve the symptoms, the effect of those who are not obvious need to be taken orally at the same time, itraconazole, terbinafine and other drugs to help the treatment. 2. Sweat herpes: sweat herpes is a special type of eczema, can be manifested as blisters on the soles of the feet, itching, burning sensation and other symptoms, blisters may cause peeling on the soles of the feet after drying up, such patients can be applied locally tretinoin ointment, tacrolimus ointment, salicylic acid ointment, urea cream and other medications, to help improve the peeling, itching and other symptoms. 3. Drug rash: drug rash in the exfoliative dermatitis type of drug rash, erythrodermic drug rash, etc. can be manifested as the soles of the feet sock-like peeling symptoms, is a more serious form of drug rash, such patients need to stop the use of allergy-causing drugs in a timely manner, drink more water or intravenous fluids to accelerate the discharge of the drug, to give loratadine, vitamin C, calcium, small doses of hormones (eg, prednisone) and other medications to help anti-allergy treatment. 4. Vitamin deficiency: If the patient has a deficiency of vitamin A, B vitamins, etc., it may also lead to the phenomenon of peeling skin on the soles of the feet, such patients can take multivitamin tablets, adjust the dietary structure, strengthen the nutrition, and improve the relevant symptoms. The soles of the feet peeling recommended timely medical treatment, physician guidance for standardized treatment, do not self-medication.