There are many causes of itching and pain in the anal region. The first one, which is more common, is perianal eczema, such as long-term fungal infections, which can easily lead to radiolucency of the perianal skin, sometimes scratching causes local oozing, and feces or mucus stimulates the perianal skin leading to itching and pain. Second, if the patient has anal fissures, such as long-term dry stool, damage to the anal canal skin fissures, under the stimulation of the lesion can easily lead to itching and pain in the anal area, the pain is more intense, usually can be relieved after the stool. Thirdly, itching and pain in the anal area may also be caused by long-term oral medication, such as colchicine and quinidine, which can also lead to anal itching and long-term scratching leading to breakage, thus causing pain. Therefore, there are many causes of itching and pain in the anus, and visual examination and, if necessary, rectal examination should be performed to clarify the diagnosis.