Feeling a little pain in the empty stomach if it is caused by gastrointestinal diseases such as duodenal ulcer, you can take omeprazole and other drugs to reduce the stimulation of gastric acid on the mucous membrane, if it is caused by hyperthyroidism, you can take methimazole and other drugs to slow down the body’s metabolism. 1. Gastrointestinal diseases: the phenomenon may be gastritis, duodenal ulcer and other gastrointestinal diseases, resulting in increased secretion of gastric acid, gastric acid stimulation of the gastrointestinal mucosa, food digestion and absorption of food after eating fast, there will be a little pain in the stomach empty. You can take omeprazole, pantoprazole and other drugs to inhibit the secretion of gastric acid, reduce the stimulation of gastric acid on the mucous membrane, to relieve the symptom. If the patient is accompanied by Helicobacter pylori infection, eradication treatment should be carried out using the quadruple method, i.e., one proton pump inhibitor such as omeprazole + one bismuth such as colloidal bismuth + two antibiotics such as amoxicillin and clarithromycin. 2. Hyperthyroidism: the body’s metabolism is accelerated, easy to hunger, will feel empty stomach, at the same time due to gastric acid stimulation of gastrointestinal mucosa will feel stomach pain. You can take drugs such as methimazole to slow down the metabolism and relieve the feeling of an empty stomach and abdominal pain. The occurrence of empty stomach pain may also be due to other reasons.