Uric acid 500μmol / L without other joint pain and other clinical manifestations is relatively not very serious, but if the patient has gout and other phenomena, it is relatively more serious. Under normal circumstances, non-same day 2 times measured fasting blood uric acid level greater than 420μmol / L can be diagnosed as hyperuricemia. Uric acid 500μmol/L is considered a significant elevation of uric acid. If the patient uric acid 500μmol / L such as no other joint pain and other clinical manifestations, this time is relatively not very serious. In daily life, we should pay attention to eat less seafood, can drink more water and moderate exercise. Through diet and lifestyle interventions, the uric acid may be reduced to normal, if the uric acid is not reduced to normal levels, it is recommended that medication be administered under the guidance of a doctor. If the patient’s uric acid is 500 μmol/L and accompanied by symptoms of gout, it is relatively serious. Need to follow the doctor’s advice to lower uric acid treatment such as oral febuxostat, benzbromarone and other drugs. Patients with uric acid 500μmol / L, it is recommended to go to the hospital rheumatology and immunology department for consultation, and actively cooperate with the doctor’s treatment.