The main difference between IVF I and IVF II is the different ways and indications. 1. Different methods: IVF generation and IVF generation two are called in vitro fertilization-embryo transfer, both to take eggs and sperm, the difference is that generation one is in the incubator sperm and egg free combination to form embryos; generation two due to the lack of sperm vitality need laboratory technicians to artificially assisted insemination, also known as ICSI. 2. Different indications: the first generation is more suitable for infertile couples with blocked fallopian tubes, endometriosis, ovulation disorders and normal male sperm. As for the male partner’s severe oligospermia, which can’t make the woman pregnant with normal fertilization, it is necessary to use the second generation of IVF technology, which can greatly improve the success rate of fertilization. Before doing IVF, both the woman and the man need to be examined separately to clarify the reasons for the inability to conceive, and then choose the appropriate way to solve the infertility problem under the guidance of the doctor. If you have any other questions, it is recommended to consult a professional doctor for guidance.