Pyelonephritis and glomerulonephritis are different in terms of lesion sites, clinical manifestations and treatment methods. 1. Site of lesion: pyelonephritis involves renal pelvis and calyces, which can be manifested as congestion and edema of the mucosa of the lesion site, small abscesses under the mucosa, and may involve the renal cortex to form a wedge-shaped foci; while glomerulonephritis involves the glomeruli and basement membranes and other parts of the kidneys. 2. Clinical manifestations: the former mainly has low back pain, fever, chills and other systemic symptoms, as well as urinary symptoms such as urinary frequency, urinary urgency, urinary difficulties, etc.; the latter is mainly glomerulonephritis hematuria, proteinuria, edema, and hypertension, blood creatinine increase. 3. Treatment: the former is mainly treated with antibiotics against gram-negative bacilli, such as quinolone antibiotics (levofloxacin); the latter can be self-cured in some patients, and in severe cases, glucocorticosteroids (prednisone) can be used in combination with immunosuppressants (cyclophosphamide). The above medication should be used in accordance with the doctor’s instructions, and should not be used without authorization, so as not to aggravate the condition. It is recommended that patients go to the relevant departments of the hospital in a timely manner, under the guidance of a professional doctor, complete the relevant examinations, so as to clarify the diagnosis of the disease, and receive standardized treatment.