HPV 53 positive can not be said to be common, can be said to be in the clinical more common. HPV 53 is a high-risk type of HPV virus, which is relatively common in the clinic, but most of the infections are transient and do not cause obvious clinical symptoms, patients do not need to take special treatment, and will gradually clear the virus by itself. However, there are some patients with persistent HPV 53-positive infections, which, if left untreated, can easily lead to cervical intraepithelial neoplasia, and may even lead to cervical cancer. HPV 53 positive is recommended for regular review, if persistent positive occurs, you need to actively cooperate with the doctor with medication, usually take topical medication, such as interferon, povidone suppositories, etc., for antiviral treatment. Treatment should be in accordance with medical advice.