Cholecystitis is a common digestive disorder with a relatively high incidence. During an attack, patients often experience severe upper abdominal pain, so the timely application of antispasmodic and analgesic drugs after a clear diagnosis can greatly relieve patients’ afflictions. When an acute attack of cholecystitis occurs, severe upper abdominal pain may occur. As the disease progresses, it may lead to jaundice when the bile ducts become inflamed or when the lymph nodes in the hepatic hilum become enlarged. Timely application of antispasmodic and analgesic drugs at this time can greatly relieve the patient’s pain. For mild pain, scopolamine can be administered orally or intramuscularly. However, when severe pain cannot be relieved, atropine can be applied intramuscularly or nitroglycerin sublingually, and of course, strong analgesics, such as pethidine, can be used. The specific medication should be combined with the clinical condition and the doctor’s guidance. In addition, for patients with cholecystitis with cholelithiasis, patients with severe abdominal pain that cannot be relieved after the application of drugs should be promptly removed surgically, and of course, for those who are suspected of perforation or whose condition worsens due to ineffective medical treatment, surgery should be considered.