The main causes of anterior ankle pain are related to trauma, inflammation, degenerative disease, tumor growth or over exertion. 1. Trauma: If the anterior side of the ankle is strained by sports or external factors that cause local injuries, such as tendon and ligament injuries or even metatarsal fractures, it is easy to directly cause pain or even swelling symptoms. 2. Inflammation: In the anterior aspect of the ankle, if there is local inflammation, such as tendonitis or fasciitis, the stimulation of inflammation can cause pain. 3. Degenerative lesions: If you often bear weight or exercise strenuously, the anterior side of the ankle joint may have degenerative lesions as you grow older, which may cause anterior side of the ankle pain. 4. Tumor growth: if there is a local tumor growth in the anterior side of ankle, such as bone tumor, the tumor presses the surrounding tissues and produces the occupying effect, which triggers the symptom of anterior side of ankle pain. 5. Excessive fatigue: if you run for a long time or perform other strenuous exercise, the anterior part of the ankle will be contracted frequently, which will easily produce local muscle fatigue, thus triggering anterolateral pain phenomenon. If the pain is more serious, you can go to the orthopedic consultation, under the guidance of professional physicians to identify the cause of the disease and then targeted treatment, to prevent the later generation of motor dysfunction.