Whether nephritis with three plus signs of occult blood can come down needs to be assessed according to the cause of the disease and cannot be generalized. If it is acute glomerulonephritis, most patients can come down after symptomatic supportive treatment; if it is chronic glomerulonephritis, it may or may not come down after treatment. Acute glomerulonephritis: acute onset, with hematuria, proteinuria, hypertension, edema, oliguria and renal function impairment as common clinical manifestations. Acute nephritis after streptococcal infection is the most common, after symptomatic supportive therapy, rest and low-salt diet and other treatments, most patients hematuria can generally disappear. Chronic glomerulonephritis: the condition is prolonged, the condition is slow progress, the rate of progress of the lesion individualization varies greatly. Whether urinary occult blood three plus can be reduced is related to the patient’s compliance, whether the treatment is timely, the type of pathology and symptoms. If the patient’s renal function is normal and the type of pathology is mild (e.g., mild tethered proliferative nephritis, etc.), hematuria may improve after treatment such as active blood pressure lowering and reduction of urinary protein. If the patient’s renal function is severely impaired, the type of pathology is more serious and often recurs due to infection (tonsillitis, etc.), it may not come down. If patients with nephritis have occult blood with three plus signs, it is recommended to go to the hospital in time, and standardize the treatment under the guidance of nephrologists, and not to use drugs blindly.