Myocardial ischemia refers to myocardial damage caused by an imbalance between myocardial oxygen consumption and coronary artery oxygen and blood supply. Ischemia may cause impaired oxidative metabolism and promote anaerobic metabolism, leading to the accumulation of anaerobic metabolites, such as lactic acid accumulation. Clinical manifestations usually include chest tightness, weakness, and dizziness, and in severe cases, angina pectoris and heart failure. When the myocardium is severely ischemic, the following drugs can be chosen: 1. Nitrate drugs: the more common drug is nitroglycerin tablets. The anti-myocardial ischemic effect of nitrate drugs is clear, which can reduce the heart load by dilating the arteries and coronary arteries, increase the coronary blood flow and relieve the patient’s symptoms of myocardial ischemia, but avoid complications such as hypotension; 2. beta-blockers: they can improve the symptoms of myocardial ischemia and inhibit the enhancement of myocardial contraction and acceleration of heart rate. Improve the balance between myocardial oxygen supply and oxygen demand, improve myocardial metabolism, etc. Common ones are metoprolol, atenolol, etc. But note that it is prohibited in patients with severe bradycardia, atrioventricular block and other diseases; 3, calcium antagonists: patients with myocardial ischemia can also choose calcium antagonist drugs, such as nifedipine, diltiazem, etc., which can lower blood pressure, improve myocardial blood supply, inhibit myocardial contraction, etc. In addition, because the occurrence of myocardial ischemia is related to conditions such as coronary artery disease, hyperlipidemia, and thrombosis, additional lipid-lowering drugs, antiplatelet drugs, thrombolytic drugs, and anticoagulant drugs are often required for patients with related conditions. Therefore, the degree of disease and clinical symptoms vary among patients, and the use of drug therapy should be analyzed on a case-by-case basis, and a suitable treatment plan should be selected according to the doctor’s recommendations. If the patient’s condition is more serious, drug therapy may not be effective, and other treatment options, such as interventional therapy or surgery for coronary artery bypass grafting, can be chosen to prolong the patient’s survival.