Small lymph nodes in the hepatoportal region mean enlarged lymph nodes in the hepatoportal region of the liver. Lymph nodes are tissues involved in the body’s immune function, and they are also found in the hilar region of the liver, mainly draining lymphatic fluid from the gastrointestinal and biliary system lymphatic vessels around the liver, playing a certain immune role, and causing enlarged lymph nodes in the event of lesions. When there are small lymph nodes in the hilar region, it can be seen in cholecystitis, cholangitis and other peri-hepatic inflammation, and anti-infection treatment is needed at this time; malignant tumors such as hepatocellular carcinoma and gastric carcinoma can also cause enlarged lymph nodes in this area, and surgery is usually needed. In addition, if lymph node tuberculosis occurs in hepatoportal area, it will also cause enlargement, and anti-tuberculosis treatment is needed in this case. When small lymph nodes are found in the hilar region, it is recommended to have further examination to clarify the cause of the disease and standardize the treatment under the guidance of doctors.