Vaccination does not necessarily correlate with the development of leukemia. Patients with leukemia should be given medication (imatinib mesylate, arsenite, etc.) or stem cell transplantation after clear typing. 1. Vaccination is a nationally prescribed immunization procedure. Various prophylactic injections and vaccines are generally inactivated live strains of viruses or biological agents. Generally speaking, there is a possibility of fever and localized swelling after vaccination, but it will not lead to a reaction of the immune system. It is possible that there is no direct correlation between vaccination and leukemia. 2. When leukemia is diagnosed, the type of leukemia should be clarified before treatment is given. For chronic granulocytic leukemia, oral imatinib mesylate is preferred, and allogeneic hematopoietic stem cell transplantation is also available. For acute promyelocytic leukemia, arsenic acid, retinoic acid, and other medications can be given, and the cure rate can be greater than 90%. If chronic lymphatic leukemia, early stage does not need special treatment, regular observation can be done, and progressive stage can be given ibrutinib and other treatments. For the same disease, patients with different physical conditions and different stages of the disease, the treatment methods are different, and standardized treatment should be carried out under the guidance of doctors.