Tacrolimus is a topical immune regulating drug that can be used to treat eczema, atopic dermatitis, hormone dependent dermatitis, etc. Most people experience increased symptoms and tingling when using Tacrolimus for the first 3 days, and the symptoms will be well relieved on the 4th day. If the itching is still too itchy after 4 days or even longer, it means that you are allergic to the ingredients of Tacrolimus, you need to stop using Tacrolimus and switch to other medications. The itching is particularly bad and you can take oral anti-allergy medications, including loratadine, epinastine, epinastine, etc. If you are really uncomfortable, you can use topical hormone ointments, including hydrocortisone butyrate cream, halometasone cream, eloson cream, etc., for a short period of time, not for a long time.