Bitter mouth and dry mouth may be caused by gastrointestinal diseases, it is recommended to go to the regular hospital, gastroscopy and breath test, if it is confirmed that the peptic ulcer, you can follow the doctor’s advice oral bismuth, omeprazole, metronidazole, levofloxacin quadruple drug eradication of H. pylori. It is important to pay attention to three regular meals, eat more dietary fiber, less spicy and greasy food, and a light diet. Gingivitis and mouth ulcers can also cause dry mouth and bitterness, which can be treated with oral metronidazole anti-inflammatory therapy. Diabetic patients with high blood glucose can also cause dry mouth and bitterness. They should consult the endocrinology department of a regular hospital, improve insulin release and glucose tolerance test, and take oral hypoglycemic drugs such as metformin, acarbose or subcutaneous insulin injection to lower sugar smoothly.