Granulocyte deficiency with fever is usually seen in patients with hematologic disorders such as leukemia, which is usually due to inadequate granulocyte production, resulting in a vicious cycle of immune deficiency and decreased resistance to disease and the involvement of leukocytes in the immune response when combined with bacterial or viral infections, usually requiring a combination of broad-spectrum antibiotics for anti-infective therapy.
Granulocyte deficiency with fever is also seen in some tumor patients, mainly due to the death of a large number of granulocytes when tumor cells break down the body’s normal cells, causing white blood cells and lymphocytes to participate in the resistance, resulting in granulocyte deficiency and a febrile response due to the immune response.
The presence of granulocyte deficiency with fever usually requires a combination of bone marrow imaging or ultrasound and other imaging tests to determine the cause, and depending on the cause, the treatment options are chemotherapy and radiation therapy for leukemia and surgical resection for tumors depending on the location and size of the tumor to relieve symptoms.