Abstract OBJECTIVE: This article describes the etiology and eradication of recurrent oral ulcers. METHODS: The etiological description in the treatise is presented, and statistical clinical data, including erythrocyte immunoassay, are presented. The treatment methods for improving restoration of immune function are described, using western immune boosters and kidney tonics equivalent to western immune boosters. RESULTS: The abnormal erythrocyte immunity of recurrent oral ulcers is clinically significant, and improving the restoration of maintaining normal immune function can eradicate recurrent oral ulcers. CONCLUSION: The key to the etiology of recurrent oral ulcers is abnormal immune function of the organism, and improvement and restoration of maintaining normal immune function can eradicate recurrent oral ulcers. The often-missed cervical lymphatic tuberculosis comorbidity further reduces the immune function of the body, so treating the combined cervical lymphatic tuberculosis at the same time can satisfactorily restore the immune function. Chinese medicine is a great treasure trove of immune-regulating drugs that should be actively explored in depth, widely used, and summarized and promoted. Some authors believe that immunotherapeutic drugs will become a very important treatment in the 21st century, and our experience illustrates this point.
Recurrent mouth ulcers are common, with a prevalence of nearly 20%, also known as recurrent aphthous mouth ulcers, which often recur, are very painful, affect eating, and are not easily cured by general treatment. In fact, recurrent mouth ulcers immune function is not normal, restore immune function can be eradicated.
Etiology
The etiology is currently considered to be immunological major cellular immune abnormal metaplasia. Pathology proves that the cells infiltrating the lamina propria of the mucosa in the early stage of recurrent oral ulcers are mainly lymphocytes, indicating that the early stage of oral ulcer development is dominated by cell-mediated immune response. Song Jianzhong reported that cellular immune function tests performed on elderly patients with recurrent mouth ulcers showed a decrease in CD4, a lower CD4/CD8 ratio (CD cluster of differentiation is a differentiated population of T cells), and a lower lymphocyte conversion rate than normal. QI Jun reported that OKT3 and OKT4 were decreased in patients with recurrent stomatitis, while OKT8 and OKT4/OKT8 ratios were normal (OKT is a monoclonal antibody antibodies OKT series used by an American ORTHO company in the past, OKT3 is equivalent to T3. The proliferation capacity of lymphocytes induced by phytohemagglutinin was significantly lower than that of the normal group, and it was initially assumed that the cellular immune function was low. Wu Baoxuan reported that patients with relapsing stomatitis had an imbalance of T cell subsets (T cells are called thymus dependent lymphocyte), no change in T3 and T4, T8 was higher than the healthy group, and the ratio of T4/T8, (T3, T4 ,T8 are cell subsets) was lower than the healthy group, and plasma and erythrocyte lipid peroxides were associated with T lymphocytes. The close relationship between plasma and erythrocyte lipid peroxidation and T lymphocytes may be involved in the acute onset of recurrent stomatitis. Immune complexes (IC) in the blood circulation of about 40% of patients are higher than normal. IC can generally be cleared by phagocytes, and when clearance is not sufficient it can be deposited on the basement membrane of the vessel wall, which can activate complement, attract neutrophils to cluster and release lysosomal enzymes to lyse tissue, causing vascular inflammation and tissue necrosis to form ulcers. Therefore, it is believed that the occurrence of recurrent oral ulcers may be a type III (immune complex-mediated) metaplasia. Immune function is influenced by genetics, infection, trauma, overwork, emotions, mental, nutritional, and endocrine relationships.
Clinical information
1. In this paper, we counted a total of 300 patients with recurrent oral ulcers in the Department of Immunopathology; 185 males (0.617) and 115 females (0,383); age: 46 cases (0.153) from 0-14 years, 228 cases (0.76) from 15 to 60 years, 26 cases (0.087) ≥ 61 years; duration of disease: 73 cases ≤ 1 year ( 0.243, 2-10 years 153 cases (0.51), >10 years 74 cases (0.247); combined cervical lymphatic tuberculosis 285 cases (0.95)
2. Erythrocyte immune function tests.
Schedule 1 Measurement of erythrocyte immune function in recurrent oral ulcers
Test items Number of cases Average value of patients Normal value P Meaning
RBC C3bRR
(erythrocyte C3b receptor wreath rate) 24 lO.4±4.6 l6.2±2.7 ＜0.001 highly significant RBCICR
(erythrocyte immune complex wreathing rate) 24 9.1 ± singular 6 4.8 ± 0.12 <0.001 highly significant RFER (erythrocyte immune complex wreathing rate)
C3b receptor wreath promotion rate) 24 127.58±39.4 189±28,3 <0.001 highly significant RFIR (erythrocyte immunity)
C3b receptor wreath inhibition rate) 24 42±8.4 34.8±sunglasses6 <0.001 highly significant
Treatment
Since the key to recurrent oral ulcer disease is the abnormal immune function of the body, this paper focuses on the treatment principle of improving, restoring and maintaining normal immune function so that recurrence, or cure, can be achieved. The cause of abnormal immune function of the organism is affected by the following factors: overwork, bad mood, mental tension, poor nutrition, tobacco and alcohol, anemia, trauma, disease, infection, pollution, heat and cold, chemicals, some drugs such as hormones, age, etc.
There are many ways to improve immune function, including herbal medicine, western medicine, oral medicine, injection, food therapy, living arrangement, etc. Our experience choose more kinds, the more serious the treatment the better the effect, the longer the time needed, after the improvement can pick a few and cheap and convenient methods to maintain.
1, Western drugs are levamisole, cimetidine (or ranitidine), inosine, multi-resistant methotrexate, card slow Shu, mushroom polysaccharide tablets, sodium deoxynucleotide (D, N.A). Topical cimetidine can be applied topically.
2.Chinese herbal medicines include Zhenqi Fuzheng Punch, Liu Wei Dihuang Wan, Tonic Zhong Yi Qi Jiu, Fishoil, Acanthopanax, Bai Ling Capsule (Cordyceps), Lingzhi, Astragalus, He Shou Wu, Fructus Lycii, Jujube, Jin Yin Hua, etc.
3, injections have tracheitis vaccine, polymyxin, placental lipopolysaccharide, thymidine, transfer factor, interferon, etc.
4, not rescue do not use adrenal corticosteroids, because it will reduce immune function.
5, quit smoking and alcohol, alcohol and tobacco reduce the immune function, someone in the family smoking to quit smoking, passive smoking also suffer.
6, avoid overwork, avoid emotional problems, prevent trauma, viral and bacterial infections, including cervical lymphatic tuberculosis, which is often missed, because these will further reduce immune function.
7, improve the immune function of food are dates, citrus, hawthorn, garlic, onion, onion, ginger, carrot, roti, mushrooms, soybeans, green beans, loofah, cucumber, pumpkin, eggplant, cauliflower, leek, seaweed, nori, etc.
Efficacy
To illustrate the efficacy of the treatment 100 patients were followed up and the results were as follows: 62% were effective (no more recurrence), 27% were effective (much better) and 11% were ineffective. Recurrent mouth ulcers were very satisfactory after improving immune function and were cured within a few months. Those who were effective were seen to be well, but sometimes they were still offending because they were not treated seriously, and if the immune function was not good, they were offending again. Those who are ineffective are those who have not been treated for some reasons, some due to pregnancy, some due to busy work, travel without buying medicine, or unwilling to take medicine, etc. This paper also uses the patient’s condition before and after treatment to illustrate the efficacy, and introduces four case histories.
(1) Recurrent oral ulcer, hypertension, coronary heart
Medical record number: 888 Female, 68 years old, retired cadre.
She was first diagnosed on August 16, 1994. For 6 years, she had recurrent mouth ulcers, which receded on this side and forked up on the other side, and were painful, especially at night, and could not be eaten because of the aggravation of acidity and saltiness. Our department diagnosed the cause of immune deficiency. Give histamine globulin subcutaneous injection, once a week, tracheitis vaccine once a week, intradermal injection, each time about 0.04 ml, meclizine oral and topical dressing, 2 months after the mouth ulcers no longer appear. The patient’s hypertension was stabilized by giving aspirin in small doses, vitamin E, vitamin C, and pansentine taken once daily, and captopril gradually reduced to half a tablet daily.
(2) Recurrent stomatitis, chronic pharyngitis, hypertension, coronary heart
Patient record number: 1190, female, 60 years old, chief nursing officer.
1995, 4.11 initial diagnosis, the patient since 1988 pharyngeal itching, foreign body sensation, severe cough, can urinate pants, white sputum, black sputum on dry, 2 years of oral ulcers, recurrent, pain, had used film paste, oral vitamin B2, vitamin BCO, C ineffective. Since 1995.4.11 in our department with bronchitis vaccine, once a week intradermal injection, each time about 0.04 ml, histamine globulin subcutaneous injection, once a week, each time 1 stick. Metformin was administered 3 times a day with 1 tablet. Treatment for 3 months, the oral ulcer disappeared, pharyngitis was relieved, hypertension took Shoubisan, and now blood pressure is 130/70.
(3) Neurodermatitis, chronic pharyngitis, recurrent oral ulcers, vaginitis
Medical record number: 1189 Female 57 years old cadre
Initial diagnosis 1995.4.l 1. Coughing in 1973 at the age of 35 during twin pregnancy, coughing after delivery, aggravated in 1993, dry and painful red throat, easy to catch cold, tiredness, tinnitus, stomach vomiting acid, unable to eat cold food (caused by 40 years of work in a yarn factory and uneven diet) recurrent oral ulcers since 1994, tongue rotten this year. Frequent urination with six flavored Dihuang Jiu saw light.
She was given cimetidine, intradermal tracheitis vaccine, histamine globulin injection, placental lipopolysaccharide injection, decoction of astragalus, heshouwu, silver fungus, honeysuckle, fat sea and jujube, and no more oral medication was given because of poor stomach. My daughter also had vaginitis and asked for tracheitis vaccination. On July 21, 1995, she came and said she was well, and her daughter’s neurodermatitis cleared up with the vaccine.
(4) Recurrent mouth ulcers, colds, cervical lymphatic tuberculosis, rickets
Medical record No. 348 Male 2 years and 9 months Child
Initial diagnosis 2000.8.8. duration of disease since 1998 (2 years) 7 months since birth diarrhea, easy to catch cold, 3 times a month, excessive sweating, night sweats, poor appetite, thin. White 1 year old recurrence of oral ulcers, including tongue map tongue, penicillin, vitamin B, compound B effect is poor, give static point thymus phthalide when map tongue disappeared, stop static point again. Check the cervical lymph nodes two side soybean large, mild chicken chest, visible Hao’s sulcus beads. Treatment: isoniazid, vitamin B, levamisole, inosine, date, bronchitis vaccine. In 2000.11.11, the follow-up examination reported that he had not caught a cold since the treatment and his sweating had decreased, so he continued the treatment. 2001.4.1, his appetite had gradually improved and his map tongue had basically disappeared. 2007 follow-up examination still did not commit any crime.
Discussion
1, immune function on the pathogenesis and prevention of the relationship: poor immune function is the key cause of recurrent infections and immune metamorphosis disease. Metaplasia refers to the perversion and abnormality of immunity. Our treatment restores and maintains normal immune function, and the patient’s recurrent mouth ulcer, which has been difficult to treat for many years, is cured. The drugs we choose to improve immune function are inexpensive but work as well as the expensive ones, such as levamisole, inosine, all of which have thymus-like effects, and polymyxin, which produces high titers of interferon in the body. Our experience in improving immune function treatment requires a combination and a long time to be effective. We do not advocate treatment with immune suppressants such as hormones. The use of vitamins and anti-inflammatory drugs alone is also not the solution.
2, combined with tuberculosis infection: the key to the development of recurrent infections and allergic diseases is the poor immune function of the body, and those with poor immune function are also susceptible to infection by tuberculosis bacteria in the air and in the respiratory tracts of every man, woman and child. Cervical lymphatic tuberculosis is one of the earliest tuberculosis infections, which is often missed due to chest X-ray (-), and nodulin test and tuberculosis antibodies in case of poor immune function (one). Because tuberculosis infection further reduces immune function, the effect of anti-tuberculosis treatment should be satisfactory only for patients with combined tuberculosis at the same time.
3, red blood cell immune function: red blood cell immunity like the white blood cell immune system has a variety of immune functions. After improving the immune function treatment, the red blood cell immune function measurement will be changed from abnormal to normal.
4.Immune function of Chinese medicine: Chinese medicine has great treasures in adjusting immune function. As explored by immune methods, herbal kidney supplementation is equivalent to the improvement of immune function in Western medicine.
Some scholars predict that in the 21st century, drugs that regulate immune function will become an important class of drugs and replace other drugs. Our experience also shows that this argument is correct.