Patients with controllable symptoms of depression can get the New Crown vaccine, while patients with uncontrollable symptoms of major depression are not recommended to get the New Crown vaccine. Patients with depression will have significant anxiety and in severe cases may even experience mental disorders such as hallucinations and delusions. Most patients will have recurrent episodes that do not easily heal. Patients in this mental state are prone to strong resistance to vaccination, making it difficult to administer the vaccine. According to the technical guidelines for vaccination against the new coronavirus issued by the Health Care Commission, people with depression who have stable mood control and good medication control are not contraindicated for vaccination against the new coronavirus and are recommended for vaccination. If the symptoms of depression are uncontrolled, uncontrollable behaviors such as patients injuring themselves or engaging in self-harm may occur at the time of vaccination, and it is impossible to predict whether these behaviors will occur, so vaccination of patients with major depression should be withheld. In addition, patients with major depression need to take antidepressant drugs for a long time for treatment, such as doxepin, paroxetine, and sodium valproate, which are common drugs for treating depression. There is a lack of corresponding theoretical clinical data on whether antidepressant drugs will affect the New Crown vaccine or produce other adverse reactions. Therefore, the New Crown vaccine is currently not recommended for depressed patients with unstable mental status who are taking medications on an ongoing basis.