With the popularity of medical checkups, many people are found to have thyroid nodules, often with multiple nodules on ultrasound. It is generally believed that multiple thyroid nodules are benign and therefore people are reluctant to undergo further testing and treatment. However, this view is often biased. The former common belief that a single thyroid nodule is malignant and multiple nodules are benign is no longer true. Patients with multiple thyroid nodules should first have their thyroid function checked, and if there are any abnormalities, they should go to internal medicine to rule out endocrine disease; if the thyroid function is normal, they should go to surgery to see if surgery is needed. For multiple thyroid nodules less than 10 mm in diameter, if ultrasound does not reveal fine calcification, microcalcification or sand-like calcification in the nodule, regular ultrasound follow-up can be performed, and surgery may not be required if the nodule does not increase in size. Especially for those who have nodules with calcification and rich blood supply, or those who have abnormal lymph nodes in the neck, or those who have nodules that increase rapidly in a short period of time and have hoarseness and pressure symptoms, or those who are older than 40 years old or have a history of previous neck radiation, surgery should be actively performed to avoid missing malignant tumors of the thyroid gland, delaying the disease and endangering the health and life of the patient. In conclusion, patients who find thyroid nodules must pay full attention to them and actively seek medical treatment. Do not take it lightly because you think that multiple nodules must be benign diseases, so as not to miss the best time for treatment and cause serious consequences.