A large cerebral infarction occurred at the age of 80 years, and the patient was in serious condition and could not be treated with thrombolysis because the age window for thrombolysis was exceeded. Conventional treatment is given to activate blood circulation and remove blood stasis, improve brain metabolism, antioxidant therapy, and cerebral protection therapy. You can use blood-activating and stasis-transforming drugs, such as Shuxuequan dots, and you can sedate Ozagrel sodium chloride injection. Nutritional brain cells and brain protection are given with Edaravone injection as a sedative. General treatment is to regulate blood pressure, blood pressure should be controlled to 150-160mmHg, low pressure around 100mmHg, also keep the airway open, oxygen, if necessary to give tracheotomy. Prevent cerebral edema and lower intracranial pressure by alternating glycerol fructose, mannitol, and tachyphylaxis, paying attention to ion. Prevent respiratory tract and urinary tract infections, turn and tap the back regularly to prevent bedsores, enhance nutrition, give nutritious food by nasal feeding, and increase resistance.