Liver metastasis of pancreatic cancer can be treated by chemotherapy combined with local minimally invasive treatment, surgery and other comprehensive treatment. 1. Local minimally invasive treatment: liver metastases with less than three foci, the largest lesion less than or equal to 3 centimeters that are not suitable for surgery, and the foci are not close to large blood vessels or located on the surface of the liver can be considered to be treated by radiofrequency or microwave ablation, and combined with chemotherapy. Commonly used chemotherapeutic drugs include gemcitabine and albumin-binding paclitaxel. 2. Surgery: For liver metastases less than or equal to 3 foci or metastases confined to a certain liver segment, to ensure that the volume of the remaining liver after surgery is sufficient, and the patient can tolerate the surgery, surgical resection can be considered, and combined with chemotherapy. For those who have no indication for surgery, chemotherapy can be given first, and for those who achieve complete remission and have indication for surgery, surgery is also feasible. Patients with liver metastasis of pancreatic cancer should go to regular hospitals in time and take targeted comprehensive treatment measures under the guidance of professional doctors.