Sore throat, coughing and spitting yellow sputum, most often caused by bacterial infections of the upper respiratory tract, the treatment is based on medication, common medications include cough suppressants, expectorants, antibacterial drugs, antiviral drugs, etc.. 1. Cough suppressants: If the patient’s cough is severe, drugs can be used to suppress the cough, commonly used drugs are Guai Mei tablets, codeine and so on. 2. Expectorants: For those who have more sputum or difficulty in coughing up sputum, expectorants can be used under the guidance of physicians, commonly used drugs such as carbocysteine, bromhexine, aminobromine, etc., which can dilute sputum and make it easy to cough up. 3. Antibacterial drugs: according to experience or sputum culture results, the use of antibiotics for treatment, commonly used drugs such as amoxicillin, cefuroxime, levofloxacin. Sore throat, coughing and spitting yellow sputum, may also be caused by other diseases, should go to the hospital in a timely manner, under the guidance of the doctor for treatment, so as not to delay the condition. The use of drugs should follow the doctor’s instructions.