Early syphilis is cured when the symptoms disappear and RPR turns negative after regular treatment, so it can be said to be cured and will not recur, but if treated with other methods because of penicillin allergy, even if the symptoms disappear and the RPR titer decreases, there is a possibility of recurrence. In addition, if contact is made with a syphilis patient again, it can also lead to reinfection, which is manifested by the appearance of symptoms of syphilis or RPR turning positive or titers rising. Although syphilis patients produce antibodies in their bodies, these antibodies are not protective and therefore can be re-infected and develop the disease. Most of the damage of advanced syphilis cannot be cured, a few can only stabilize the disease, and most of those with severe symptoms have difficulty improving. Whether syphilis is cured, relapsed or reinfected needs to be determined by an experienced medical professional.