The etiology of acute pancreatitis is not fully understood and lacks a unified explanation, which may include the following. 1, common channel obstruction about 70% of people biliopancreatic duct common opening in the Vater jug, due to a variety of reasons, including jug abdominal stones, roundworms or tumor compression and obstruction, or biliary proximal stones down, resulting in inflammatory stenosis of the sphincter of Oddi, or biliary stones and their inflammation caused by spasm edema of the sphincter, or duodenal papillitis, opening fibrosis, or papillary paraduodenal diverticulum, etc., all make bile The pancreatic duct pressure rises, causing the pancreatic vesicles to rupture, bile pancreatic juice and activated pancreatic enzymes seep into the pancreatic parenchyma, with highly active pancreatic protease for “self-digestion”, pancreatitis occurs. According to statistics, about 30 to 80% of the gallbladder disease caused by cholelithiasis. 2, overeating Alcohol has a direct toxic effect on the pancreas and local stimulation, resulting in acute duodenitis, papilledema, spasm of the sphincter of Oddi, resulting in obstruction of bile drainage, coupled with overeating causes a large amount of pancreatic juice secretion, the sudden increase in pressure in the pancreatic duct, triggering the disease. Some statistics about 20-60% of acute pancreatitis occurs after overeating alcohol. 3, vascular factors Experimentally confirmed: the injection of 8 to 12 μm granular material into the pancreatic artery blocking the end of the pancreatic artery, can lead to acute hemorrhagic necrotizing pancreatitis. It can be seen that the disease can occur when the pancreatic blood flow is impaired. When the activated trypsin flows backward into the pancreatic interstitium, it can cause high spasm of small arteries, embolism of small veins and lymphatic vessels, which can lead to pancreatic necrosis. 4, infection factors Inflammatory infections of the abdominal cavity and pelvic organs can cause pancreatitis through blood flow, lymph or local infiltration and other diffusion. Typhoid fever, scarlet fever, septicemia, especially mumps virus has a special affinity for the pancreas, which also easily causes acute pancreatic morbidity. 5, surgery and trauma abdominal trauma such as blunt trauma or penetrating trauma, can cause pancreatitis. Post-operative pancreatitis accounts for about 5-10% of the cases, which may occur as follows: (1) trauma or surgery directly injures pancreatic tissue and ducts, causing edema, pancreatic duct obstruction or impaired blood supply. (2) Injury or surgery with hypovolemic shock, inadequate perfusion of blood to the pancreas, or microthrombosis. (3) Decreased pancreatic enzyme inhibitory factor in the pancreatic fluid after surgery. (4) High pressure of contrast agent injection during ERCP examination can cause pancreatic injury, temporary hyperamylasemia, or acute pancreatitis. (5) Rejection after organ transplantation and the application of immunosuppressive agents can also induce. (6) Other In conclusion, it is agreed by more than 100 years of research that pancreatic obstruction, with/without duodenal fluid, bile reflux, coupled with impaired blood flow, pancreatic enzymes are activated and pancreatic defense mechanisms are damaged, and cause this disease.