Blisters on the lower body in men are blisters on the skin of the genital or perineal area. There are possible causes such as genital herpes, contact dermatitis, insect bite dermatitis, and drug rash. 1. Genital herpes: genital herpes caused by herpes simplex infection may cause blisters, ulcers and other manifestations in the genital area, or around the anus, which can lead to blisters on the skin of the genital or perineal area. 2. Contact dermatitis: local skin contact with external sensitizers, such as chemical fiber underwear, underwear, soap, shower gel and other products, may also lead to genital or perineal skin blistering, itching, erythema and other symptoms. 3. Insect bite dermatitis: genital or perineal skin, by mosquito bites may cause skin blisters, rashes, itching, resulting in genital and perineal skin blisters. 4. Drug rash: allergic reaction after local or systemic medication may also lead to blistering, itching and even peeling of the genital or perineal skin. Genital or perineal skin blisters may have other causes, you should go to the hospital in time for examination, clear diagnosis and follow the doctor’s instructions for treatment.