If pneumonia worsens after hospitalization, measures such as changing drugs, checking for specific pathogens and treating underlying diseases should be taken according to the cause of the worsening. 1. Change of medication: Common causes of pneumonia include bacteria, viruses, etc. In addition, medication should be chosen according to the patient’s age, the presence or absence of underlying diseases, the presence or absence of aspiration, the length of hospitalization, etc. If symptoms worsen, the appropriate choice of medication should be considered. If symptoms worsen, consider whether the drugs are appropriate and whether it is necessary to change antibiotics or add other drugs; 2. Examining whether there are special pathogen infections: for some patients who live in ICU, have immune deficiency, or use hormone or broad-spectrum antibiotics for a long time, they are more likely to be succumbed to multi-drug-resistant bacteria and fungal infections, which makes the effect of conventional treatment not good, and at this time, we can change the antibiotics or add the fungal medication according to the results of the drug sensitivity test or the fungal examination; 3. Treatment of underlying diseases: patients suffering from cardiac insufficiency, pulmonary heart disease, other organ insufficiency or paralysis, because of heavy cardiopulmonary burden or inability to actively expectorate, which may lead to poor treatment of pneumonia, can apply for multidisciplinary joint consultation, strengthen the assisted expectoration and other multiple measures to control the primary disease. Pneumonia exacerbation, should be comprehensively considered lung lesions, drug selection, individual patient specificity, underlying disease and other multiple factors, under the guidance of the doctor to adjust the treatment program.