Bi-atrial enlargement of the heart is often accompanied by cardiac systolic dysfunction and is easily combined with heart failure and arrhythmias. The goals of treatment are to control heart failure and arrhythmia, alleviate myocardial immune damage, and improve the survival rate and quality of life of patients. 1. Heart failure: beta-blockers and angiotensin-converting enzyme inhibitors (ACEI) can be used in the early stage to reduce myocardial damage and slow down the progression of the disease. Those with fluid retention in the later stages should limit sodium intake and use diuretics reasonably. 2. Arrhythmia: there is a risk of embolism and there is no contraindication to the application of aspirin, it is advisable to take long-term oral aspirin; there has been a wall thrombosis and embolism need long-term antithrombotic therapy, such as warfarin. 3. Improve myocardial metabolism: use coenzyme Q10, coenzyme Q10 has improved myocardial energy metabolism, stabilize the cell membrane and anti-free radicals. People with bi-atrial enlargement of the heart should consult the doctor in time, improve the examination, clarify the cause and diagnosis, and standardize the treatment under the guidance of professional physicians.