Bilateral lower extremity arterial intimal thickening with plaque needs to be treated with medication, and if it is accompanied by severe stenosis, stent implantation is needed. Bilateral lower limb intimal thickening with plaque is caused by atherosclerosis of both lower limb vessels, and further imaging is needed to determine the degree of stenosis. For less severe stenosis, drug treatment is preferred to prevent thrombosis by applying antiplatelet aggregation drugs, such as aspirin and clopidogrel; Stabilize plaque by applying statin drugs to lower blood lipids, such as Rosuvastatin and Simvastatin, and applying drugs to improve the circulation of the lower limbs to relieve symptoms, such as Prostadil. Meanwhile, to control the risk factors, it is recommended to eat a light diet, control weight, quit smoking and drinking, and control blood pressure, blood lipid and blood sugar. If the stenosis is severe in both lower limbs, stent implantation is needed to open the occluded vessels. If there are bilateral lower extremity arterial intimal thickening with plaque, it is recommended to go to the vascular surgery department for further treatment.