Elderly people with high differential pressure can take amlodipine, valsartan and other antihypertensive drugs. Elderly people with high differential pressure is related to atherosclerosis, atherosclerosis will lead to a decrease in the elasticity of blood vessels, manifested in increased systolic blood pressure, diastolic blood pressure is normal or slightly reduced, manifested in increased pulse pressure difference, mostly manifested in pure systolic blood pressure increase. Elderly patients can take oral calcium antagonists for treatment, commonly used representative of the drug amlodipine, can play the role of vasodilatation, and at the same time can improve myocardial blood supply, suitable for elderly patients. Elderly patients can also take valsartan, belonging to the angiotensin II receptor antagonist, also has the effect of vasodilatation, suitable for renal insufficiency, cardiac insufficiency of the elderly hypertensive patients to take. Adverse effects of amlodipine include dry stools, ankle edema, tachycardia, constipation, etc. It is contraindicated in patients who are allergic to the components of the drug and have hypotension. Adverse reactions to valsartan include flu-like symptoms, rhinitis, bronchitis, nausea, elevated blood potassium, dizziness, hypotension, etc. It is contraindicated in patients who are allergic to the components of the drug, severe renal insufficiency, and women who are breastfeeding during pregnancy. Elderly patients with hypertension can choose a variety of antihypertensive drug treatment, to choose the appropriate antihypertensive drug treatment for elderly patients under the guidance of physicians.