Most of the patients will be in great pain in the first few hours before the death of pancreatic cancer, and the possible scenarios include: severe pain, breathing difficulty, mental abnormality, metastatic symptoms and so on. 1. Severe pain: pancreatic cancer can invade the abdominal plexus and cause severe pain. In addition, when bone metastasis occurs, there will be persistent severe bone pain. 2. Difficulty in breathing: pancreatic cancer can form a large amount of ascites in the advanced stage, which leads to diaphragm moving up and compressing the volume of thoracic cavity, thus causing difficulty in breathing. In addition, long-term severe pain can also inhibit breathing. 3. Mental/neurological abnormalities: Long-term severe pain, disease torture, malnutrition and other factors can cause a series of mental symptoms, such as anxiety, euphoria, delirium, hallucinations, lethargy, coma until death. 4. Metastatic symptoms: brain metastasis can occur in the late stage of pancreatic cancer, causing intracranial pressure increase, severe headache, dizziness, violent vomiting, blurred vision and other manifestations. 5. Other symptoms: some patients may be accompanied by continuous or intermittent low fever and abnormal blood sugar. If pancreatic cancer is suspected or diagnosed, it is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instructions to cooperate with the treatment, so as to improve the prognosis of patients and prolong the survival period.