Ulcerative colitis with blood in the stool can be treated by using medications such as mesalazine and methotrexate, and surgery. The doctor will determine which treatment to use according to the patient’s specific situation. 1. Taking medications: Ulcerative colitis is usually caused by intestinal immune dysfunction and other reasons. Recurrent ulcers can damage blood vessels in the mucosal layer or submucosal layer, which can lead to blood in the stool. It is recommended to take anti-inflammatory drugs such as mesalazine enteric-coated tablets and osalazine sodium capsules to promote the healing of ulcers so as to stop bleeding. 2. Intravenous injection: patients with ulcerative colitis who have a lot of blood in the stool should go to the hospital in time and take intravenous injections, such as injections of spearhead pit viper hemagglutinin, methotrexate injection and other drugs for treatment. 3. Surgery: If the amount of bleeding after defecation in ulcerative colitis is not large, you can choose medication. If the amount of bleeding is large, surgical treatment is needed, such as total colectomy plus ileal storage bag anal canal anastomosis. When the diagnosis of ulcerative colitis blood in the stool, should follow the doctor’s instructions standardized treatment. The above drugs need to be used under medical supervision.