The normal value of total bilirubin is usually 3.7 to 17.1, which is categorized into indirect bilirubin and direct bilirubin. Jaundice can be considered if it exceeds 34.1. Total bilirubin of 18.42 is considered to be slightly elevated. If there are no clinical symptoms and the indirect and direct bilirubin are normal, observation can be continued. If high bilirubin is caused by disease, it should be treated according to the specific cause. Common causes include hemolytic anemia, bile duct obstruction, liver disease, etc. Treatments include correction of bad habits, medication, surgery, and so on. There are many reasons for high total bilirubin, which need to be combined with indirect and direct bilirubin values to identify the disease. 1. Hemolytic anemia: indirect bilirubin is elevated, direct bilirubin is normal. There are many causes, such as thalassemia, thrombocytopenic purpura, and infections. Treatment needs to be clear cause for treatment, such as autoimmune cause can use drugs such as glucocorticoid such as dexamethasone, immunosuppressant such as cyclosporine, cyclophosphamide. Thalassemia can be treated with surgical splenectomy. 2. Biliary obstruction: direct bilirubin is elevated, indirect bilirubin is normal. It is common in biliary tract stone, tumor, inflammation and congenital biliary atresia. Generally, surgery is needed to remove stones from the bile duct, remove tumors and relieve biliary obstruction. Antibacterial drugs such as penicillin can be taken for biliary tract inflammation. 3. Liver disease: Indirect bilirubin and direct bilirubin are elevated, which can be caused by hepatitis, cirrhosis and other diseases. Firstly, it is necessary to change the bad habits, such as avoiding staying up late at night, quitting smoking, quitting drinking and so on, and secondly, it is possible to take liver-protecting drugs, such as glutathione and so on. Total bilirubin 18.42 can also be seen in other causes, it is recommended to improve the relevant examination in time to clarify the cause, under the guidance of the doctor to carry out targeted treatment, please do not take medication, so as not to delay the condition.