The normal value of abnormal prothrombinogen is <20ng/ml, and the current high of more than 20,000 may be due to various reasons leading to vitamin K deficiency, primary liver cancer and other reasons. 1. Various causes of vitamin K deficiency: such as the use of bicoumarin anticoagulants, long-term use of cephalosporin antibiotics neonatal natural hemorrhagic disease. Because in the case of vitamin K deficiency, liver cells can not synthesize normal coagulation factors, but can only synthesize abnormal prothrombin without coagulation function. 2. Primary hepatocellular carcinoma: Since the synthesis of prothrombin precursors by cancer cells is impaired, it will also lead to obvious elevation of abnormal prothrombin. In addition, long-term oral anticoagulant drugs and intestinal flora disorders will also lead to increased abnormal prothrombin. People with elevated abnormal plasminogen need to go to the hospital for further examination to clarify the cause of elevated abnormal plasminogen and under the guidance of the doctor for treatment.