Caused by very dry lips drink water does not work for many reasons, excluding the body sweating or high temperature, dry environment for a long time, such as factors, common pathological causes are diabetes mellitus, uremic syndrome, dry syndrome, etc., the specific situation needs to be analyzed specifically. 1. Diabetes mellitus: diabetic patients due to a large number of osmotic diuresis, water discharged too much, there will be always dry mouth, drinking water does not significantly alleviate the symptoms, through a clear diagnosis, good control of blood glucose, the symptoms will be reduced accordingly. 2. Uremia: patients with uremia will have severe dry mouth due to the large amount of dilute urine discharged, if they don’t drink water, it will cause the patient’s symptoms to worsen significantly, and even dangerous, can be supplemented with antidiuretic hormone, the symptoms can be relieved quickly. 3. Dry syndrome: due to the salivary glands around the mouth by autoimmune damage, saliva secretion is reduced, the mouth is always dry, when eating all need to swallow water, talking will also keep drinking water, through the rheumatology and immunology Department of a clear diagnosis, anti-immune treatment, the symptoms can be relieved. The symptoms can be relieved through the anti-immune treatment after a clear diagnosis in the rheumatology and immunology department.