Nowadays, the abuse of Valium drugs is becoming more and more serious, both in daily life and in clinical use. Especially clonidine, because of its long-acting and powerful sleep-aiding effect, more and more people are applying it, but not many understand its side effects. 1, common adverse reactions are; abnormal excitement, nervousness and irritability (paradoxical reactions), muscle weakness; less common are: behavioral disorders, inability to focus thinking, irritability (common in children), confusion (intolerable), hallucinations, depression; rare are; rash or itching (allergic reactions), sore throat, fever or bleeding abnormalities, petechiae or extreme fatigue or weakness (hematocrit) . 2, persistent appearance to be noted are; more common are inflexibility, unstable walking, drowsiness, related to the dosage, the most serious at the beginning of treatment, will gradually disappear with continued administration; less common are blurred vision, constipation, diarrhea, dizziness or dizziness, headache, increased airway secretion or salivation, nausea, vomiting, urination disorder, slurred speech, dry mouth. 3. Persistent confusion, severe drowsiness, shakiness, persistent slurred speech, stumbling, abnormally slowed heartbeat, shortness of breath or difficulty, and severe weakness may be symptoms of drug overdose and need to be noticed. Drowsiness, ataxia, behavioral disturbances such as agitation, excitement, restlessness, and aggression are common; sometimes anxiety, depression, dizziness, fatigue, vertigo, slurred speech; occasionally excessive salivation, rash, diplopia, and gastrointestinal reactions. Long-term application produces drug dependence. Rapid intravenous injection has a certain inhibitory effect on the heart and respiration. Special populations should be noted: 1. Children are prone to behavioral changes, the incidence of which is 2-5%, manifested by agitation, excitement, excessive movement and rage. Occasionally, rash and thrombocytopenia, gastrointestinal discomfort, salivation, parotid enlargement, enuresis, diplopia and excessive bronchial secretion are seen. 2. Long-term use of clonidine in women can cause menstrual irregularities and affect ovulation; taking Valium in the early stages of pregnancy may cause congenital malformations in the fetus. 3, chronic adrenal insufficiency patients, when taking the product, may promote the adrenal crisis. 4, patients suffering from severe emphysema should not take Valium. And Valium has the effect of inhibiting the respiratory center, thus aggravating the hypoxic response. Treatment of insomnia long-term use of Valium drugs may have greater side effects on the body, should try to reduce the use of Valium, the use of Chinese medicine treatment.