Mediastinal lymph node metastasis of lung cancer often indicates that the disease has deteriorated and it is difficult to be cured by treatment. Patients can improve the prognosis of the disease through surgical treatment, radiotherapy, chemotherapy, targeted therapy and immunotherapy. If the metastatic lesion in mediastinal lymph node of lung cancer compresses the surrounding lung tissues and organs and causes respiratory difficulties, the lesion can be removed to relieve the compression under the comprehensive evaluation of doctors. In addition to surgical treatment, radiotherapy, chemotherapy, targeted therapy and immunotherapy can kill some tumor cells to a certain extent, help shrink the tumor foci and inhibit tumor proliferation and metastasis, so as to improve the prognosis of the disease and the quality of life of patients. When mediastinal lymph node metastasis of lung cancer occurs, it is recommended to go to the hospital to receive standardized treatment in time to avoid delaying the condition.