Granulation of onychomycosis is caused by local bacterial infection and improper nail trimming, which leads to unhealed local injury and granulation, and is often treated by local debridement and trimming of diseased nails. 1. Local debridement: patients need to use iodine povidone or saline to fully clean the wound and expose the granulation, or use sterile blades or scissors to remove the purulent epidermis and fully expose the granulation under the guidance of the doctor. 2. Trimming the sick nail: fully assess the degree of nail deformity, such as partial deformity, only need to cut off the strip of sick nail, to reduce local irritation, if the deformity is more serious, and accompanied by other nail diseases, need to comply with the doctor’s advice to perform a total nail extraction. Patients with onychomycosis need to go to regular hospitals for treatment in a timely manner, and they need to trim their nails correctly in their daily life, and they need to go to the dermatology department of the hospital in a timely manner in case of granulation.