A critically high total bilirubin value means that the patient’s total bilirubin value is much higher than the normal reference value, and the liver cells may be damaged, which should be taken seriously and seek medical attention promptly. Total bilirubin is the sum of direct and indirect bilirubin values in the body, and the liver plays an important role in the metabolism of bilirubin. The normal value of total bilirubin ranges from 5.13 to 22.24 μmol/L. A value higher than the standard indicates that the liver cells may be damaged. More than two times the normal value is a mild increase, two to five times is a moderate increase, and more than five times is a severe increase. When the total bilirubin value belongs to the critical high value, it means that the patient has obvious total bilirubin elevation, and the degree is not light, should be under the guidance of the doctor targeted treatment. During the treatment, pay attention to develop good habits, do not stay up late, eat a light diet, etc., to protect the liver can play a better role in the recovery of the liver.