Large pimples generally refer to acne, which can be treated through medication, physical therapy, and daily life conditioning. 1. Medication: Vitamin A cream, adapalene gel, antibiotics such as fusidic acid cream, mupirocin ointment, clindamycin and other topical preparations can be used. Salicylic acid cream and sulfur lotion can be used to inhibit the growth of acne bacteria. 2. Physical therapy: LED blue light or red light can be used for irradiation treatment, in addition to the use of fruit acid, salicylic acid and other chemical exfoliation therapy. 3. Daily life management: You can use water or suitable cleansing products to remove excess oil flakes and bacterial mixtures on the surface, appropriately limit the intake of high-glycemic index foods and milk, keep bowel movement smooth, and avoid staying up all night. All of the above medications should be used under a doctor’s supervision. It is recommended that patients go to the hospital in a timely manner and follow the doctor’s instructions for standardized treatment.