Locally advanced breast cancer refers to a large breast lump size or enlarged axillary lymph nodes, metastatic lymph nodes with adhesions to surrounding tissues, etc. Immediate surgery for locally advanced breast cancer may have too much flap tension to close and a high rate of residual tumor lesions or metastatic lymph nodes. Nowadays, the rise of neoadjuvant chemotherapy (preoperative chemotherapy) can make locally advanced breast cancer down-stage, and surgery can be performed after the primary lesions and lymph nodes are reduced, which can achieve better results. Some patients can also choose preoperative radiotherapy or preoperative endocrine therapy, both of which are preoperative adjuvant treatments, expecting to shrink the lesion after treatment to achieve the goal that the lesion can be removed. Systemic advanced breast cancer refers to stage IV breast cancer, which means that there are already organs outside the breast invaded by the tumor, such as breast cancer liver metastasis, breast cancer lung metastasis, breast cancer bone metastasis and so on. Generally speaking, the prognosis of advanced breast cancer is poor, but about 10% of patients can still achieve a survival of 5 years or more. After finding distant organ metastases from breast cancer, it is important to treat them aggressively according to different conditions. Similarly, the treatment of breast cancer metastases is divided into local treatment and systemic treatment. Since distant metastasis suggests that tumor cells may exist in all parts of the body, systemic treatment is essential. Chemotherapy and endocrine therapy in systemic treatment are applied according to the patient’s specific situation. For metastases that appear during treatment, it is generally considered that the drugs used previously are resistant and should be replaced with second-line drugs. Some breast cancers with metastases can be treated with additional local therapy. If the metastases in the liver or lung are single and small, patients can undergo resection of the metastases first if their conditions permit, so as to obtain pathological diagnosis on the one hand and destroy the tumor cells to the maximum extent. For pulmonary metastases and pleural metastases, pleural fluid can be released by thoracentesis, and then chemotherapy drugs can be injected into the chest cavity. Pain arising from bone metastases can be treated with local radiotherapy, or intra-isotope radiotherapy, and bisphosphonates. Localized metastases in the chest wall can be surgically removed and localized chest wall followed by radiotherapy. Aggressive treatment of metastatic breast cancer can achieve good results and have a long survival for some patients. For fairly advanced breast cancer, the limitation of medical development makes there is no good method at present. The treatment for this part of patients is focused on reducing pain, improving quality of life and prolonging life.