The most common cause of cerebral thrombosis is in situ thrombosis, and the most important factor in the formation of in situ thrombosis is atherosclerosis of the cerebral vessels, and the rupture of unstable plaque will form in situ thrombosis. In the clinic, if there is hypertension, diabetes, hyperlipidemia, smoking or family history of early-onset atherosclerosis, it is likely to form cerebrovascular atherosclerosis. The progression of cerebrovascular atherosclerosis will result in the formation of unstable plaques, and if the fibrous cap structure of the unstable plaque ruptures, it will cause the exposure of the lipid pool and cause the blockage of the distal vessels by lipids. The exposed endothelium will also activate the coagulation system and cause cerebral thrombosis. In case of cerebral thrombosis, it is important to go to the emergency department first for active emergency treatment and, if necessary, thrombolytic therapy.