Gallstones always hurt, depending on the cause of the patient’s pain, different treatment methods are needed. First, if the stones in the gallbladder are embedded in the gallbladder duct and cause pain, it is recommended that the patient should be actively treated with anti-infection. After controlling the inflammation of the gallbladder, laparoscopic cholecystectomy should be performed as soon as possible, which is a minimally invasive surgery with little trauma and fast recovery. Second, if the pain is caused by stones in the common bile duct, the patient may have chills, high fever, jaundice and other manifestations of acute cholangitis. If not treated in time, the patient may develop life-threatening infectious shock. It is necessary to perform biliary exploration as soon as possible to relieve the bile duct pressure and remove the stones to restore the patency of the bile duct. Third, if biliary stones cause acute pancreatitis, it will also manifest as pain in the upper abdomen. In this case, the inflammation of the pancreas should be clarified by CT and a large amount of fluid should be given as soon as possible.