If the urinary tract infection is particularly painful, it needs to be treated in the hospital, preferably by taking a urine culture and drug sensitivity test to select a sensitive antimicrobial agent for treatment. After the inflammation has gradually returned to normal, the pain may also be reduced. If there is no condition for urine culture, it is recommended to select cephalosporin or quinolone antibiotics empirically, such as oral cefixime capsule or levofloxacin hydrochloride capsule for anti-infection treatment. Patients with severe pain can take oral diclofenac sodium capsules or fenpropathrin extended-release capsules for symptomatic pain relief treatment. At the same time, patients need to drink more water and urinate more often. Drinking more water can increase the metabolism of drugs, and urinating more often can excrete urine containing bacteria as soon as possible to reduce patients’ pain symptoms. For patients with severe pain, if necessary, intramuscular injection of brucizine hydrochloride injection or dulcolax injection can be used to temporarily relieve pain and switch to intravenous antibiotics for treatment, such as intravenous infusion of levofloxacin hydrochloride injection, or injectable cefuroxime sodium or cefoxitin sodium to strengthen anti-infection treatment.