The pathological signs mainly include Babinski’s sign, Oppenheim’s sign and Gordon’s sign, which mainly reflect the lesions of upper motor neurons. If the patient has lesions in the brain or spinal cord, that is, lesions of upper motor neurons, the paralysis can lead to spastic paralysis, and the patient’s pathological signs are positive at this time. If there is a lesion in the extremities, that is, a lesion in the nerves below the spinal cord, it is a paralysis of the lower motor neurons, and the pathological reflexes are usually negative. If necessary, an MRI can be performed to clarify the findings. If a cranial lesion is suspected, a cranial CT or cranial MRI can also be performed to further clarify the findings.