Patients with hemorrhoids presenting with significant pain are considered to have thrombotic emboli formed in the nucleus during acute attacks. The pain caused by external hemorrhoids can be treated with oral nimesulide dispersible tablets or the application of aminogest tablets for pain relief. The most effective treatment for hemorrhoids is to opt for surgery, which requires a surgical operation under anesthesia to remove the lesion and the patient’s painful symptoms can be completely improved. Patients with hemorrhoids who have a combination of local soft tissue infections can also experience painful symptoms and can opt for anti-infection treatment with broad-spectrum cephalosporins combined with metronidazole. Because repeated inflammatory stimulation can also lead to increased pain symptoms, you can also take appropriate oral anti-infective drugs.