Glycoantigen 125 of 500 U/mL is not normal. Glycoantigen, also known as CA125, is a glycoprotein that is normally expressed in the epithelial cells of the body’s luminal tract, and its normal reference value should be below 35 U/mL, so a Glycoantigen 125 of 500 U/mL is not a normal laboratory indicator. Although Glycoantigen 125 cannot directly diagnose cancer, it is very meaningful in early detection and prediction of cancer. Its elevation is most common in women’s ovarian cancer, but also in breast cancer, colon cancer, stomach cancer, pancreatic cancer, lung cancer, and also in some non-tumor diseases such as ovarian cysts, pancreatitis, cirrhosis of the liver and so on. If Glycoantigen 125 reaches 500U/mL, you should go to the hospital as soon as possible to clarify the cause, and the doctor will make individualized diagnosis and treatment plan to avoid delaying the condition.