Enlarged periumbilical mesenteric lymph nodes may be caused by mesenteric lymphadenitis, lymph node tuberculosis, malignant lesions, etc., which need to be treated according to the cause. 1. Mesenteric lymphadenitis: For infections of intra-abdominal organs, such as chronic enteritis, cholangitis, etc., and respiratory infections in children, they may lead to periumbilical or mesenteric lymphadenitis. If it is a bacterial infection, antibiotics such as cefixime and amoxicillin are needed to treat it; if it is caused by virus, acyclovir and ribavirin can be taken to treat it. 2. Lymph node tuberculosis: if it is lymph node tuberculosis caused by periumbilical mesenteric lymph node enlargement, it can be treated with anti-tuberculosis drugs such as isoniazid, rifampicin and pyrazinamide. 3. Malignant lesions: lymphoma, lymphoblastic leukemia, lymphatic metastasis of malignant tumors (e.g. intestinal cancer, cholangiocarcinoma, pancreatic cancer, hepatocellular carcinoma, etc.), etc., all of which may cause mesenteric lymph node enlargement. Surgery, radiotherapy, chemotherapy (e.g. doxorubicin, bleomycin, etc.), bone marrow transplantation, etc. are required after the diagnosis of the primary disease. If you find enlarged mesenteric lymph nodes around the umbilicus, you should consult a doctor for a clear diagnosis and follow the doctor’s instructions.