Diabetic patients is not an absolute contraindication to Irbesartan Hydrochlorothiazide drug, if diabetic patients need to use Irbesartan Hydrochlorothiazide for treatment, it can be used, need to follow the doctor’s instructions to use. Irbesartan hydrochlorothiazide is a combination preparation for the treatment of essential hypertension. Adverse reactions such as dizziness, edema, syncope, tachycardia, nausea, and vomiting may occur with the drug. Contraindications to the drug include severe renal impairment; intractable hypokalemia and hypercalcemia; and severe hepatic impairment. Diabetic patients need to consult a professional physician for the use of medication, under the guidance of the physician reasonable use of medication, so as not to cause serious adverse reactions.