In general, acute epididymitis infusion can be effective in 1~2 days, which may vary depending on the condition and individual’s physique and drug sensitivity. Acute epididymitis can be effective with medication for about 1~2 days, such as the reduction of epididymal pain and swelling, and the relief of fever. Acute epididymitis is mainly treated by using antibiotics, commonly used drugs include cephalosporins, quinolones, macrolides and so on. Sexually transmitted epididymitis is mostly treated with cephalosporin antibiotics, which can be added with levofloxacin and doxycycline, etc. Epididymitis caused by E. coli infection is mostly treated with ofloxacin or levofloxacin. The above drugs need to be used under the guidance of a doctor.