Irbesartan hydrochlorothiazide tablets may cause potassium deficiency. Irbesartan hydrochlorothiazide tablets is a combination of Irbesartan and hydrochlorothiazide, in which hydrochlorothiazide is a kind of diuretic, which has the effect of sodium and potassium excretion. Diuretics can enhance the antihypertensive efficacy of Irbesartan. The main adverse effect is hypokalemia, which is more likely to be caused by poor diet during the administration of the drug, and therefore electrolytes need to be monitored during the administration to avoid hypokalemia. Irbesartan Hydrochlorothiazide Tablets are mainly used to treat patients whose blood pressure cannot be effectively controlled by Irbesartan or Hydrochlorothiazide alone. Other adverse reactions include dizziness, edema, tachycardia, nausea, and dry mouth. The main contraindications are allergy to drug components, intractable hypokalemia, hypercalcemia, severe hepatic impairment, lactation and so on. The use of specific drugs should consult a professional physician, do not take on your own to avoid adverse reactions.